Emily-Rose is Depp's 14-year-old daughter with his former girlfriend, Vanessa Paradis. The couple broke up in 2012. Depp's currently engaged to Amber Heard, who he met while filming The Rum Diary. He was last seen in The Lone Ranger.
Manson appeared on the most recent season of Californication. His last album, Born Villain, came out in 2-12.
Depp and Manson are both big fans of gonzo writer Hunter S. Thompson. The actor has appeared in two movies adapted from Thompson's books, Fear and Loathing in Las Vegas and The Rum Diary.