Harold & Kumar Escape from Guantanamo Bay (2008)
At a roadblock with Neil Patrick Harris at the wheel and Harold (John Cho) and Kumar (Kal Penn) hiding in the backseat, Harris eats a bag of mushrooms. When Officer Ron Fox (Rob Corddry) notices it's Harris, he heeps on the praise as Harris hallucinates, seeing himself on a unicorn. "If you want to know the secret of being you will come with us," the vision reveals. As the unicorn rides away, Harris says, "I love you." Fox replies: "I love you too, Mr. Patrick Harris."
Directed by Jon Hurwitz and Hayden Schlossberg; also starring Danneel Ackles
Knocked Up (2007)
Ben (Seth Rogan) and Pete (Paul Rudd) take mushrooms and go to a Cirque du Soleil show in Las Vegas. "I'm freaking out, man," Ben says as the acrobats nail their routines. "The mushrooms are turning on me. I can't deal with this shit, man." Ben and Pete bolt from their seats and race up the aisle.
Directed by Judd Apatow; also starring Katherine Heigl
Know Your Mushrooms (2008)
Eleven years before Fantastic Fungi, documentarian Ron Mann did a deep dive in this mushroom movie. Mann is also known for Grass (1999).
Dani (Florence Pugh) attends a pagan festival in Sweden where she has a bad trip on mushrooms. In this clip, directer Ari Aster details how he used warping and other techniques to create the stony visual effects.
Natural Born Killers (1994)
Serial killers Mickey (Woody Harrelson) and Mallory (Juliette Lewis) takes mushrooms and hang with Navajo shaman Red Cloud in the California desert. Sadly, this encounter does not go well for Red Cloud.
Directed by Oliver Stone; also starring Robert Downey Jr.
Newlyweds Mac (Seth Rogen) and Kelly (Rose Byrne) move next door to a wild frat. In hopes of making friends, Mac shows up with a bag of mushrooms. In this promo clip, Rogen takes several mouthfuls and says. "I'll be honest: I've eaten a lot of mushrooms in my life at times. I fried to tap into some of those feelings."
Directed by Nicholas Stoller; also starring Zach Efron
Remy (voiced by Patton Oswalt) finds a mushroom and cooks it over a chimney, which is struck by lightning. The mushroom looks like a toasty marshmallow. "You've got to taste this," he tells Emile (Peter Sohn). "It's not like a smoky taste. It's of like a ba-boom, zap kind of taste. What would you call that flavor?" "Lightening-y?" Remy says. "Lightening-y!" Emile agrees.
Directed by Brad Bird and Jan Pinkava